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|Drug Name and Strength||Acepromazine maleate (ACP) 12 mg/mL|
|Indication||Excitable, nervous, unruly or hard to handle animals; in training; to reduce excitement and stress during surgical and nonsurgical procedures, including preanaesthetic sedation, shoeing, transporting and confining temperamental horses, dentistry, mares during breeding and horses postoperatively; to calm cattle during shipment (other than for slaughter), surgical procedures, examination and electroejaculation of bulls, to facilitate branding and castration under intensive conditions.|
|Actions||Tranquilliser and sedative to control nervous and excitable behaviour. Clinically, animals respond by showing relaxation and less anxiety, while retaining coordination and awareness of environment.Acepromazine is well absorbed from the gastrointestinal tract, with more rapid onset occurring when administered prior to feeding. Acepromazine has little, if any, analgesic effect, so use in painful procedures must be accompanied by use of local anaesthetics.|
|Warnings||Administer with caution to animals exhibiting symptoms of debilitation, congestive heart failure, sympathetic blockade, hypovolaemia and shock.Do not administer to breeding stallions. Paralysis of the retractor penis muscle has been associated with the use of parenterally administered acepromazine in horses. When administered to male horses (geldings or stallions), use the lowest dose recommended to produce the required effect.Do not use in conjunction with organophosphates and/or procaine hydrochloride, as it may enhance activity and potential toxicity. As a guide, allow a three to five day interval between use of organophosphate topical and oral preparations to ensure predictable action of oral ACP.|
|Precautions||Tranquillisers are additive to the actions of other depressants, and will potentiate general anaesthesia. While the product is not intended for routine use as an anaesthetic premedication, situations may arise where general anaesthesia is required in the four to six hours following administration. Take care to reduce the induction dose, particularly of parenteral barbiturates, to avoid potentiation and additive depressant effects.Adrenaline is contraindicated to reverse hypotension resulting from acepromazine overdosage, since further depression of systemic blood pressure can result. Administer other pressor amines, e.g. noradrenaline or phenylephrine, to reverse hypotensive effects.First Aid If poisoning occurs, contact a doctor or Poisons Information Centre. Phone Australia 131 126.Disposal Dispose of empty container by wrapping in paper and placing in garbage.|
|Dosage and Administration||Give orally via dial-a-dose syringe. Individualise dosage; exceeding the recommended dose will not necessarily intensify the effect. Avoid excitement or stimulation of the animal prior to administration.Horses. 4 to 10 mL/450 kg bodyweight (0.11 to 0.27 mg/kg bodyweight) depending on degree and duration of sedation required. Mild sedation. 1 mL/100 kg before or after feeding should begin to have effect at 30 to 40 minutes; peak effect at two to four hours; total duration of effect of eight to ten hours. Medium sedation. 1.5 mL/100 kg before or after feeding should begin to have effect at 40 to 60 minutes; peak effect at two to five hours; total duration of action of ten to twelve hours. Heavy sedation. 2 mL/100 kg before feeding should have an onset of action at 60 to 80 minutes peak effect at 80 minutes to six hours; total duration of action of twelve hours.Cattle. 5 to 10 mL/450 kg bodyweight (0.13 to 0.26 mg/kg bodyweight).Tranquillising effect may be more pronounced if feed and water intake is limited during a period of five hours before dosing. See literature included with product for further details.|
|Storage||Store below 30°C (room temperature).|
|MSDS (external link)||Sedazine Paste MSDS|
|Label (external link)||Sedazine Paste Label|
|Manufacturer||Virbac (Australia) Pty Limited|