Fortekor Plus 5mg/10mg (30 tablets)
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|Drug Name and Strength||Pimobendan 5mg + Benazepril hydrochloride 10mg|
|Indication||Treatment of congestive heart failure in dogs.|
|Contraindications||Fortekor Plus is contraindicated for use in animals with hypertrophic cardiomyopathy or cardiac output failure due to aortic stenosis or pulmonary stenosis. This product is also contraindicated in animals with known hypersensitivity to pimobendan or benazepril hydrochloride. This product is contraindicated for use in animals with hypotension, hypovolaemia, hyponatraemia or acute renal failure.|
|Actions||Pharmacology Benazepril hydrochloride, a prodrug, is hydrolysed in vivo to benazeprilat, which inhibits angiotensin converting enzyme (ACE), thus preventing the conversion of inactive angiotensin I into active angiotensin II. Fortekor Plus reduces local and systemic effects mediated by angiotensin II, including vasoconstriction of arteries and veins, and retention of sodium and water by the kidney.Pimobendan, a benzimidazole-pyridazinone derivative, is a nonsympathomimetic, nonglycoside inotropic substance with potent vasodilating properties. Pimobendan exerts its stimulatory myocardial effect by a dual mechanism of action: increase in calcium sensitivity of cardiac myofilaments and inhibition of phosphodiesterase (type III). It also exhibits a vasodilating action through an inhibitory action on phosphodiesterase III activity.Pharmacokinetics Absorption. Benazepril is rapidly but incompletely absorbed from the gastrointestinal tract following oral administration. Following oral pimobendan administration, the absolute bioavailability of the active principal is 60 to 63%. The mean plasma protein binding is 93%. Metabolism. Absorbed benazepril is partially hydrolysed by hepatic enzymes to the active substance benazeprilat; unchanged benazepril and hydrophilic metabolites account for the remainder. Distribution. Peak plasma benazeprilat concentrations are attained within about two hours in both fasting and fed situations. Benazepril and benazeprilat are bound to plasma proteins and in tissues are found mainly in the liver and kidney. Repeated administration of benazepril leads to slight accumulation of benazeprilat in plasma; steady state is attained within four days. Excretion. The major part of benazeprilat is rapidly eliminated, although there is, in addition, a slow terminal elimination phase. Benazeprilat is excreted approximately equally via the biliary and urinary routes in dogs. The plasma elimination half-life of pimobendan is approximately 30 minutes and the main active metabolite elimination half-life is approximately two hours. Almost the entire dose is eliminated via faeces.|
|Precautions||Pregnancy, lactation. The safety of Fortekor Plus has not been tested in breeding animals. Fortekor Plus is therefore not recommended for use in pregnant or lactating animals. Age. The efficacy and safety of Fortekor Plus has not been established in dogs below 2.5 kg bodyweight.First Aid If poisoning occurs, contact a doctor or Poisons Information Centre. Phone Australia 131 126.|
|Dosage and Administration||Fortekor Plus is a fixed combination product which should only be used in dogs which require active substances to be administered concomitantly at this fixed dose. Tablets should be administered to the dog twice a day, approximately 12 hours apart (morning and evening). Each dose should be given approximately one hour before feeding, using a dosage of 0.125 mg/kg bodyweight pimobendan and 0.25 mg/kg bodyweight benazepril hydrochloride.|
|Storage||Store below 25°C (air conditioning). Store in the original packaging to protect from moisture. Any unused half tablet should be returned to the open blister space and inserted back into the cardboard box. Tablet halves should be used within 24 hours.|
|MSDS (external link)||Not specified|
|Label (external link)||Fortekor Plus Label|
|Manufacturer||Elanco Animal Health|