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|Drug Name and Strength||Thiamazole (methimazole) 2.5mg|
|Indication||Stabilisation of feline hyperthyroidism as a pre-operative therapy, and long-term treatment of feline hyperthyroidism.|
|Contraindications||Do not use in pregnant or lactating queens; in cats suffering from systemic disease such as primary liver disease or diabetes mellitus; in cats showing signs of autoimmune disease; in animals with disorders of white blood cells such as neutropenia or lymphopenia; in animals with platelet disorders or coagulopathies (particularly thrombocytopaenia); or in cats with hypersensitivity to thiamazole or the excipient polyethylene glycol.|
|Actions||Controls excessive production of thyroid hormones thyroxine (T4) and triiodothyronine (T3) to achieve euthyroidism.|
|Precautions||When an animal has concurrent renal disease, the benefits of thyroid control can be balanced against those of renal disease by aiming to keep the T4 levels in the upper normal range. Concurrent treatment with phenobarbital may reduce the clinical efficacy of thiamazole. Concurrent treatment with benzimidazole wormers is known to reduce the hepatic oxidation of these actives and may lead to increases in circulating levels. Thiamazole is immunomodulatory, therefore this should be taken into account when considering vaccination programs.Product is harmful if swallowed. Do not swallow. Wash hands after use. Do not break or crush tablets. Thiamazole may cause birth defects. Women of childbearing age are advised not to administer this product. Children and pregnant women should not come into contact with this drug. Keep children and pregnant women away from vomitus, faeces and urine of treated cats. Wear protective gloves to prevent direct contact with vomitus, faeces and urine of treated cats and/or when cleaning up broken or moistened tablets. Do not handle this product if you are allergic to thyroid hormone inhibitors.First Aid If poisoning occurs, contact a Poisons Information Centre. Phone Australia 131 126. Additional information is in the Material Safety Data Sheet.Disposal Dispose of empty container by wrapping with paper and putting in garbage. Unused product should be returned to the veterinary surgeon.|
|Dosage and Administration||For oral administration only. Starting regimen. 2.5 mg twice a day is recommended for all cats. Studies have shown that the incidence and severity of adverse effects are reduced if this regimen is followed. Stabilisation of feline hyperthyroidism before surgical removal of the thyroid gland. One 2.5 mg tablet morning and evening. This should ensure euthyroidism within three weeks in most cases. Long term treatment of hyperthyroidism. The starting dose should be 2.5 mg morning and evening. After three weeks, the dose should be titrated to effect, according to the serum total T4. The 5 mg tablet is suitable for cats requiring a higher dose. Whenever possible, the total daily dose should be divided into two and administered morning and evening. Tablets should not be split. The aim should be to achieve the lowest possible dose rate. Lifelong treatment is required. If more than 10 mg/per day is required, animals should be monitored particularly carefully. The dose administered must not exceed 20 mg/day. If a veterinarian is contemplating a once daily dosing regime, they should note that efficacy studies were conducted using only a twice daily dosing regimen; consequently, the efficacy of a once daily dose has not been established. Therefore, if a once daily dose of 5 mg is required to facilitate compliance, reduced efficacy may occur. Haematological and biochemical parameters and serum total T4 should be assessed before initiating treatment, and after three weeks, six weeks, 10 weeks, 20 weeks, and then every three months. The dose should be titrated as necessary. Dose adjustment. Adjust dose by increments of 2.5 mg/day.|
|Storage||Store below 25°C (air conditioning) in a dry place. Keep container closed and protect from light.|
|MSDS (external link)||Felimazole 2.5mg Tablets MSDS|
|Label (external link)||Felimazole 5mg Tablet Label|
|Manufacturer||Dermcare-Vet Pty Ltd|