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|Drug Name and Strength||Clomipramine hydrochloride 5mg|
|Indication||When used in conjunction with behaviour modification training: treatment of stereotypic behaviours (obsessive–compulsive disorders) in dogs such as acral lick dermatitis, excessive grooming, tail chasing, and fears and phobias (including noise phobia); aid in the treatment of anxiety disorders in dogs such as destructiveness, excessive vocalisation and loss of toilet control associated with separation anxiety; aid in the treatment of urine spraying in desexed and female cats.|
|Actions||In vivo, both clomipramine and its major metabolite desmethylclomipramine are active and contribute to the broad spectrum action of Clomicalm by blocking the neuronal reuptake of both noradrenaline and serotonin (5-HT). Clomicalm therefore possesses the properties of both a tricyclic antidepressant and a serotonin reuptake inhibitor. Therapeutic levels are reached after approximately five to seven days of treatment.|
|Precautions||From its known mechanism of action, it is recommended to use Clomicalm with care in dogs with cardiac arrhythmias, epilepsy or narrow angle glaucoma. Owing to the potential for anticholinergic effects, Clomicalm should also be used with care in dogs and cats with a known predisposition to developing urinary tract obstruction or urinary retention. Clomicalm is not recommended for treatment of aggression or for treating a dog or cat with the above listed behaviours when that animal has a history or predisposition to aggressive behaviour.The efficacy and safety of Clomicalm have not been established in dogs and cats weighing less than 1.25 kg, or less than 6 months of age.Clomipramine hydrochloride is metabolised by hepatic glucuronidation. Since cats use this pathway less efficiently than dogs, special care must be taken when prescribing Clomicalm 5 in cats.First Aid If poisoning occurs, contact a doctor or Poisons Information Centre. Phone Australia 131 126.Disposal Dispose of empty container by wrapping with paper and putting in the garbage.|
|Dosage and Administration||If dispensing tablets, this must be done into another child resistant container. Dogs. 1 to 2 mg/kg bodyweight twice daily, to give a total daily dose of 2 to 4 mg/kg. Administer orally, preferably with food.In clinical trials, Clomicalm administered for two to three months, in combination with appropriate behaviour modification techniques, has been shown to favourably enhance and accelerate the response to behaviour modification in the treatment of anxiety disorders in dogs. It has also been shown to be effective in the treatment of stereotypic behaviours such as acral lick dermatitis when administered for a minimum of one month. Cats. 0.3 to 1 mg/kg bodyweight once daily. Administer orally, preferably with food.When used in combination with behavioural modification, Clomicalm is effective as an aid in the treatment of urine spraying in cats. Tailing off. Clomicalm therapy should be continued for four weeks after the clinical signs have disappeared or resolved to a level that is acceptable to the owner. Medication can then be stopped; however, it is advisable to tail off or gradually reduce the dose of clomipramine at the end of the course of treatment. Halve the dose for one week, then halve the dose again, if possible, then stop medication.When tablets are divided, administer remaining half tablet at next dosage.|
|Storage||Store below 30°C in a dry place. Store unused product in the original closed container with two sachets of desiccant.|
|MSDS (external link)||Clomicalm Tablets 5mg MSDS|
|Label (external link)||Clomicalm Tablets 5mg Label|
|Manufacturer||Elanco Animal Health|