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|Drug Name and Strength||Cephalexin 1000mg|
|Indication||Infections caused by cephalexin sensitive organisms in large dogs, including susceptible Staphylococcus aureus, E. coli, Proteus and Klebsiella. These include infections of the respiratory tract, musculoskeletal system, genitourinary tract, skin and soft tissues.|
|Actions||Cephalexin 1000 is an orally active cephalosporin (previously classified as a first generation cephalosporin) intended for oral administration in dogs and cats.Microbiology Cephalexin, like other beta-lactam antibiotics, is a bactericidal agent that causes death of bacterial cells via biological and biochemical effects on the cell wall. Cephalexin is effective against most Gram-positive aerobic cocci and several Gram-negative bacteria including Escherichia coli, Proteus mirabilis and Klebsiella. Cephalosporinase producing organisms are not susceptible.Pharmacokinetics Cephalexin is a first generation cephalosporin, is acid stable, and dosing is unaffected by food. It is a beta-lactam antibiotic, but tends to be more resistant to breakdown by beta-lactamases than most penicillins. Its bactericidal action is time dependent. Cephalexin is absorbed from the upper small intestine with little or no absorption from the stomach. Tmax is rapid; 1.5 hours in plasma and about two hours in skin. It is widely distributed throughout the body including high concentrations in blood, urine, bile, pleural fluid, pericardial fluid, synovial fluid and into cortical and cancellous bone, as well as kidneys, lungs and soft tissues. Penetration into prostatic tissue, spinal fluid, vitreous and aqueous humour is poor. Metabolism is minimal and cephalexin is excreted almost entirely by the kidneys via glomerular filtration and tubular secretion, with 70 to 100% of the dose found in urine six to eight hours after each dose. Cephalexin use should be monitored closely in animals with kidney disease. Cephalexin causes minimal gastrointestinal irritation as it is not absorbed in the stomach and, due to rapid and near-complete absorption in the small bowel, reduces disruption to large bowel microflora. Cephalexin shows low protein binding and can be used in animals with liver disorders as there is little liver metabolism.|
|Precautions||While concurrent cephalosporin allergy occurs in only about 10% of animals with penicillin allergy, use with caution in animals with a history of acute allergy to penicillin. Use of cephalexin in pregnancy is considered as Category B: low risk; and it is excreted into milk at very low levels.First Aid If poisoning occurs, contact a doctor or Poisons Information Centre. Phone Australia 131 126.|
|Dosage and Administration||15 mg/kg bodyweight orally twice daily, or 30 mg/kg bodyweight once daily, until at least 48 hours after clinical signs have subsided. Skin and genitourinary tract infections may require long-term treatment for a minimum of seven days.|
|Storage||Store below 30°C (room temperature). Protect from light.|
|MSDS (external link)||Cephalexin Tablets 1000mg MSDS|
|Label (external link)||Cephalexin Tablets 1000mg Label|
|Manufacturer||Apex Laboratories Pty Ltd|