Cartrophen Vet 10ml

100% of 100
Pentosan polysulfate sodium 100 mg/mL
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More Information
Drug Name and StrengthPentosan polysulfate sodium 100 mg/mL
Quantity10ml Bottle
IndicationRelief of pain associated with noninfectious inflammatory joint disease in dogs and as an aid in the treatment of noninfectious inflammatory joint disease in horses: (i) osteoarthritis, especially in conditions affecting multiple joints; (ii) osteochondrosis dissecans; (iii) traumatic joint and peri-articular inflammation in working and racing dogs, and for the relief of lameness and pain in horses associated with osteoarthritis or traumatic joint disease; (iv) as treatment following intra-articular surgery, but not within the first 24 hours.
ContraindicationsAdministration to dogs with clotting defects, traumatic haemorrhage, infection, hepatic or renal failure.
ActionsDisease modifying osteoarthritis drug (DMOAD).Pharmacology The pharmacological activities of pentosan polysulfate considered responsible for disease modification in osteoarthritis include the following: direct anti-inflammatory activity; direct inhibition of enzymes implicated in cartilage destruction and activation of the bradykinin, complement and fibrinolytic systems (elastase, cathepsin B, hyaluronidase); indirect modulation of cartilage degradation by reduction in tissue levels of matrix metalloproteinases (MMP) concomitant with elevation of MMP inhibitor (TIMP); reduction in activity of tumour necrosis factor-α (TNF-α) at sites of inflammation; stimulation of fibrinolysis (via increased tissue plasminogen activator (tPA) and reduced tPA inhibitor) by capillary endothelium; stimulation of release of superoxide dismutase (SOD) by capillary endothelium; stimulation of hyaluronan synthesis by synovial fibroblasts; and stimulation of chondrocyte synthesis of proteoglycans and DNA.
Dosage and Administration Dogs. Four 3 mg/kg (1.0 mL/33 kg) subcutaneous or intramuscular injections, with an interval of five to seven days between injections. Horses. Four 2 to 2.5 mg/kg (10 to 12.5 mL per 500 kg horse) intramuscular injections, with an interval of five to seven days between injections.
StorageStore below 25°C (air conditioning.) Protect from light.
MSDS (external link)Cartrophen Vet 10ml MSDS
Label (external link)Cartrophen Vet 10ml Label
Refrigerated ProductNo
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