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|Drug Name and Strength||Carprofen 50 mg|
|Indication||Analgesia, and reduce inflammation such as that seen in degenerative joint disease in dogs.|
|Contraindications||Administration to dogs exhibiting previous hypersensitivity to carprofen. Administration to cats, as there are no specific data available for use in this species. Concurrent use of carprofen with other anti-inflammatory drugs such as corticosteroids and other NSAIDs should be avoided or closely monitored. If changing anti-inflammatory products, take into account the pharmacokinetic properties of the drugs used previously when considering the delay period between individual drugs.|
|Actions||Pharmacology Carprofen is a nonsteroidal anti-inflammatory drug (NSAID) used in the treatment of inflammation and to provide analgesia. Carprofen appears to have greater activity against the cyclooxygenase-2 (COX-2) isoenzyme than COX-1, which may partly explain why carprofen appears to be less ulcerogenic than many other NSAIDs.Pharmacokinetics There is good absorption from the gastrointestinal tract following oral administration. There is a high degree of protein binding and a small volume of distribution that is mostly to extracellular sites. Carprofen is a weak acid, so it readily penetrates into inflamed tissue. Elimination is usually following metabolism by hepatic enzymes, and the less active metabolites are eliminated via a combination of faecal and urinary excretion. Urinary excretion of the unchanged drug is minimal, and relies on glomerular filtration and tubular excretion. There is also a degree of hepatic excretion and evidence of enterohepatic recycling.|
|Precautions||As a class, NSAIDs may be associated with gastrointestinal and renal toxicity. These potential effects may result in clinically significant disease in animals with underlying or pre-existing disease more often than in healthy animals. Sensitivity to drug associated adverse effects varies with the individual animal. NSAID therapy could unmask disease which has previously been undiagnosed due to absence of clinical signs. Therefore, use with caution in dogs that are less than 6 weeks of age, debilitated or aged, have existing cardiac, hepatic or renal disease, or are dehydrated, hypovolaemic or hypotensive. The safety of carprofen in pregnant or lactating animals has not been established.First Aid If poisoning occurs, contact a doctor or Poisons Information Centre. Phone Australia 131 126.|
|Dosage and Administration||2 to 4 mg/kg bodyweight/day. Dose, frequency and duration of treatment will depend on clinical response to treatment. Initial therapy at 4 mg/kg bodyweight/day given in two equally divided doses is generally recommended. Subject to clinical response, the dose may be reduced to 2 mg/kg bodyweight/day administered as a once daily dose. All dogs should undergo a thorough clinical examination and appropriate laboratory tests before introduction of NSAID therapy. During extended administration, appropriate re-evaluation and laboratory tests should be undertaken periodically.|
|Storage||Store below 30°C (room temperature).|
|MSDS (external link)||Carprofen Flavoured Tablets (Apex) 50mg MSDS|
|Label (external link)||Carprofen Flavoured Tablets (Apex) 50mg Label|
|Manufacturer||Apex Laboratories Pty Ltd|