Atopica Capsules 50mg Purple OUT OF STOCK UNTIL MID OCTOBER

93% of 100
Cyclosporin 50mg
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More Information
Drug Name and StrengthCyclosporin 50mg
Quantity15 Caps
IndicationTreatment of atopic dermatitis in dogs, and aids in the treatment of perianal fistulae in dogs. Atopic dermatitis is one of the most common allergic skin diseases in dogs, and is caused by allergens such as house dust mites or pollens which stimulate an exaggerated immune response in atopic dogs. Atopy can occur seasonally, but occurs frequently as a nonseasonal condition with summer exacerbation. The disease is chronic, recurrent and requires lifelong management, as elimination of exposure to allergens is generally impossible. Atopic dermatitis may often be complicated by bacterial or fungal infections. Clinical signs such as pruritus and skin inflammation are not specific for atopic dermatitis and therefore other causes of dermatitis should be ruled out, and serum and/or intradermal allergy testing performed to support the diagnosis of atopy.Perianal fistula is a painful, chronic and progressive inflammatory disease involving the anal and perianal area of dogs. It is characterised by inflammation and ulceration in the perianal skin that progresses to the formation of draining sinuses and fistulous tracts. Clinical signs include painful defecation and an unpleasant odour.
ContraindicationsAdministration to dogs aged less than 6 months and weighing less than 2 kg. The efficacy and safety of cyclosporin has not been assessed in dogs aged less than 6 months and weighing less than 2 kg.
ActionsCyclosporin is a selective immunomodulator that acts specifically and reversibly on T-lymphocytes. It has anti-inflammatory activities in atopic dermatitis and perianal fistulae in dogs. Cyclosporin acts specifically and reversibly on the cellular immune reaction by inhibiting resting T-lymphocytes and the antigen triggered release of lymphokines by activated T-cells. It also inhibits eosinophil recruitment and activation, keratinocyte cytokine production, Langerhans cell functions, degranulation of mastocytes, and therefore inhibits release of histamine and pro-inflammatory cytokines. Cyclosporin does not depress haematopoiesis and has no effect on the function of phagocytic cells.
PrecautionsThe tolerability of Atopica has not been studied during pregnancy and lactation. There is no evidence of teratogenicity of cyclosporin in laboratory animals. Atopica is recommended for use in breeding dogs only if the risk:benefit ratio is considered justified by the veterinarian.It is recommended to clear bacterial and fungal infections before treatment with Atopica. Infections are not necessarily a reason for drug withdrawal if they occur during treatment.As cyclosporin inhibits T-lymphocytes, it may decrease the immune response in the case of malignancy. A complete clinical examination should be performed before treatment. Lymphadenopathy or cutaneous lesions observed on treatment with cyclosporin should be regularly monitored. In dogs with known hepatic dysfunction, blood levels of cyclosporin may increase in some cases. If signs of diabetes mellitus are observed following the use of the product, e.g. polyuria or polydipsia, the dose should be tapered or discontinued and veterinary care sought. In dogs with pre-existing diabetes, it is recommended to regularly monitor blood glucose levels.First Aid If poisoning occurs, contact a doctor or Poisons Information Centre. Phone Australia 131 126.
Dosage and AdministrationGive Atopica orally, without food, at least two hours prior to or after feeding. Insert the capsule directly into the dog's mouth.Treatment of atopic dermatitis. The recommended oral daily dose of cyclosporin is 5 mg/kg bodyweight. The following dosages correspond to a minimum of 3.1 mg/kg and maximum of 6.7 mg/kg. Administer Atopica once daily until a satisfactory clinical improvement is seen, usually within four weeks. Atopica can then be given every second day. Once the clinical signs of atopic dermatitis are satisfactorily controlled, Atopica can be given every three to four days. The veterinarian will adjust the frequency of administration to the response. Dog 2 to < 3 kg bodyweight. One 10 mg capsule. 3 to < 4 kg. Two 10 mg capsules. 4 to < 8 kg. One 25 mg capsule. 8 to < 15 kg. One 50 mg capsule. 15 to < 29 kg. One 100 mg capsule. 29 to < 36 kg. One 50 mg capsule and one 100 mg capsule. 36 to < 55 kg. Two 100 mg capsules.Aid in the treatment of perianal fistulae. Limited data are available on the use of cyclosporin for the treatment of perianal fistulae in dogs. The recommended oral daily dose of cyclosporin is 7.5 mg/kg bodyweight. Side effects such as vomiting, diarrhoea and gingival hypertrophy may be observed during prolonged treatment with doses greater than 10 mg/kg daily. Clinical improvement is usually seen within four weeks. If no response is obtained within the first eight weeks, stop the treatment. Treatment for at least twelve weeks, or until four weeks after lesion resolution, is recommended to minimise recurrence. Concurrent antibiotics or analgesia may be required. Recurrence may be managed with a further course of treatment with Atopica.
StorageStore below 25°C (air conditioning).
MSDS (external link)Atopica Capsules 50mg Purple MSDS
Label (external link)Atopica Capsules 50mg Purple Label
ManufacturerElanco Animal Health
Refrigerated ProductNo
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